1RQQ
Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
Summary for 1RQQ
Entry DOI | 10.2210/pdb1rqq/pdb |
Descriptor | Insulin receptor, adaptor protein APS, BISUBSTRATE INHIBITOR, ... (6 entities in total) |
Functional Keywords | protein tyrosine kinase, adaptor protein, sh2 domain, transferase-signaling protein complex, transferase/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P06213 Cytoplasm: Q9Z200 |
Total number of polymer chains | 6 |
Total formula weight | 100999.71 |
Authors | Hu, J.,Liu, J.,Ghirlando, R.,Saltiel, A.R.,Hubbard, S.R. (deposition date: 2003-12-06, release date: 2003-12-30, Last modification date: 2024-10-09) |
Primary citation | Hu, J.,Liu, J.,Ghirlando, R.,Saltiel, A.R.,Hubbard, S.R. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12:1379-1389, 2003 Cited by PubMed: 14690593DOI: 10.1016/S1097-2765(03)00487-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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