1ROC

Crystal structure of the histone deposition protein Asf1

Summary for 1ROC

• Entry DOI: 10.2210/pdb1roc/pdb
• Descriptor: Anti-silencing protein 1, BROMIDE ION (3 entities in total)
• Functional Keywords: beta-sandwich, replication, chaperone
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Nucleus: P32447
• Total number of polymer chains: 1
• Total formula weight: 18218.87

Authors

Daganzo, S.M.,Erzberger, J.P.,Lam, W.M.,Skordalakes, E.,Zhang, R.,Franco, A.A.,Brill, S.J.,Adams, P.D.,Berger, J.M.,Kaufman, P.D. (deposition date: 2003-12-02, release date: 2003-12-23, Last modification date: 2024-02-14)

Primary citation

Daganzo, S.M.,Erzberger, J.P.,Lam, W.M.,Skordalakes, E.,Zhang, R.,Franco, A.A.,Brill, S.J.,Adams, P.D.,Berger, J.M.,Kaufman, P.D.
Structure and function of the conserved core of histone deposition protein Asf1.
Curr.Biol., 13:2148-2158, 2003

PubMed Abstract: Asf1 is a ubiquitous eukaryotic histone binding and deposition protein that mediates nucleosome formation in vitro and is required for genome stability in vivo. Studies in a variety of organisms have defined Asf1's role as a histone chaperone during DNA replication through specific interactions with histones H3/H4 and the histone deposition factor CAF-I. In addition to its role in replication, conserved interactions with proteins involved in chromatin silencing, transcription, chromatin remodeling, and DNA repair have also established Asf1 as an important component of a number of chromatin assembly and modulation complexes.

PubMed: 14680630
DOI: 10.1016/j.cub.2003.11.027

Experimental method

X-RAY DIFFRACTION (1.5 Å)