1RMX

A SHORT LEXITROPSIN THAT RECOGNIZES THE DNA MINOR GROOVE AT 5'-ACTAGT-3': UNDERSTANDING THE ROLE OF ISOPROPYL-THIAZOLE

Summary for 1RMX

• Entry DOI: 10.2210/pdb1rmx/pdb
• Related: 1RN9
• Descriptor: 5'-D(*CP*GP*AP*CP*TP*AP*GP*TP*CP*G)-3', N-[3-(DIMETHYLAMINO)PROPYL]-2-({[4-({[4-(FORMYLAMINO)-1-METHYL-1H-PYRROL-2-YL]CARBONYL}AMINO)-1-METHYL-1H-PYRROL-2-YL]CARBONYL}AMINO)-5-ISOPROPYL-1,3-THIAZOLE-4-CARBOXAMIDE (2 entities in total)
• Functional Keywords: minor-groove-dna complex, side-by-side binding, dna recognition, dna
• Total number of polymer chains: 2
• Total formula weight: 7175.32

Authors

Anthony, N.G.,Johnston, B.F.,Khalaf, A.I.,Mackay, S.P.,Parkinson, J.A.,Suckling, C.J.,Waigh, R.D. (deposition date: 2003-11-28, release date: 2004-08-24, Last modification date: 2022-03-02)

• Primary citation: Anthony, N.G.,Johnston, B.F.,Khalaf, A.I.,MacKay, S.P.,Parkinson, J.A.,Suckling, C.J.,Waigh, R.D.; Short Lexitropsin that Recognizes the DNA Minor Groove at 5'-ACTAGT-3': Understanding the Role of Isopropyl-thiazole.; J.Am.Chem.Soc., 126:11338-11349, 2004; PubMed: 15355117; DOI: 10.1021/ja030658n

Experimental method

SOLUTION NMR