1RH2
RECOMBINANT HUMAN INTERFERON-ALPHA 2B
Summary for 1RH2
| Entry DOI | 10.2210/pdb1rh2/pdb |
| Descriptor | INTERFERON-ALPHA 2B, ZINC ION (2 entities in total) |
| Functional Keywords | interferon, cytokine, anti-viral, immunomodulator, 4 helix bundle |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P01563 |
| Total number of polymer chains | 6 |
| Total formula weight | 115923.83 |
| Authors | Walter, M.R. (deposition date: 1996-11-07, release date: 1997-11-12, Last modification date: 2024-02-14) |
| Primary citation | Radhakrishnan, R.,Walter, L.J.,Hruza, A.,Reichert, P.,Trotta, P.P.,Nagabhushan, T.L.,Walter, M.R. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. Structure, 4:1453-1463, 1996 Cited by PubMed Abstract: The human alpha-interferon (huIFN-alpha) family displays broad spectrum antiviral, antiproliferative and immunomodulatory activities on a variety of cell types. The diverse biological activities of the IFN-alpha's are conveyed to cells through specific interactions with cell-surface receptors. Despite considerable effort, no crystal structure of a member of this family has yet been reported, because the quality of the protein crystals have been unsuitable for crystallographic studies. Until now, structural models of the IFN-alpha's have been based on the structure of murine IFN-beta (muIFN-beta). These models are likely to be inaccurate, as the amino acid sequence of muIFN-beta differs significantly from the IFN-alpha's at proposed receptor-binding sites. Structural information on a huIFN-alpha subtype would provide an improved basis for modeling the structures of the entire IFN-alpha family. PubMed: 8994971DOI: 10.1016/S0969-2126(96)00152-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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