1RH2

RECOMBINANT HUMAN INTERFERON-ALPHA 2B

1RH2 の概要

• エントリーDOI: 10.2210/pdb1rh2/pdb
• 分子名称: INTERFERON-ALPHA 2B, ZINC ION (2 entities in total)
• 機能のキーワード: interferon, cytokine, anti-viral, immunomodulator, 4 helix bundle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P01563
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 115923.83

構造登録者

Walter, M.R. (登録日: 1996-11-07, 公開日: 1997-11-12, 最終更新日: 2024-02-14)

主引用文献

Radhakrishnan, R.,Walter, L.J.,Hruza, A.,Reichert, P.,Trotta, P.P.,Nagabhushan, T.L.,Walter, M.R.
Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Structure, 4:1453-1463, 1996

PubMed Abstract: The human alpha-interferon (huIFN-alpha) family displays broad spectrum antiviral, antiproliferative and immunomodulatory activities on a variety of cell types. The diverse biological activities of the IFN-alpha's are conveyed to cells through specific interactions with cell-surface receptors. Despite considerable effort, no crystal structure of a member of this family has yet been reported, because the quality of the protein crystals have been unsuitable for crystallographic studies. Until now, structural models of the IFN-alpha's have been based on the structure of murine IFN-beta (muIFN-beta). These models are likely to be inaccurate, as the amino acid sequence of muIFN-beta differs significantly from the IFN-alpha's at proposed receptor-binding sites. Structural information on a huIFN-alpha subtype would provide an improved basis for modeling the structures of the entire IFN-alpha family.

PubMed: 8994971
DOI: 10.1016/S0969-2126(96)00152-9

実験手法

X-RAY DIFFRACTION (2.9 Å)