1RGZ
Enterobacter cloacae GC1 Class C beta-Lactamase Complexed with Transition-State Analog of Cefotaxime
Summary for 1RGZ
Entry DOI | 10.2210/pdb1rgz/pdb |
Related | 1GCE |
Descriptor | class C beta-lactamase, {[(2E)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ETHANOYL]AMINO}METHYLPHOSPHONIC ACID, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hydrolase, cephalosporinase, enzyme inhibition, phosphonate, beta-lactam antibiotics, drug design |
Biological source | Enterobacter cloacae |
Cellular location | Periplasm (By similarity): P05364 |
Total number of polymer chains | 1 |
Total formula weight | 39986.47 |
Authors | Nukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R. (deposition date: 2003-11-13, release date: 2004-04-06, Last modification date: 2023-08-23) |
Primary citation | Nukaga, M.,Kumar, S.,Nukaga, K.,Pratt, R.F.,Knox, J.R. Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J.Biol.Chem., 279:9344-9352, 2004 Cited by PubMed: 14660590DOI: 10.1074/jbc.M312356200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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