1RD8

Crystal Structure of the 1918 Human H1 Hemagglutinin Precursor (HA0)

Summary for 1RD8

• Entry DOI: 10.2210/pdb1rd8/pdb
• Descriptor: hemagglutinin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: glycoprotein, membrane-fusion precursor, virus/viral protein, viral protein
• Biological source: Influenza A virus; More
• Total number of polymer chains: 6
• Total formula weight: 176670.15

Authors

Stevens, J.,Corper, A.L.,Basler, C.F.,Taubenberger, J.K.,Palese, P.,Wilson, I.A. (deposition date: 2003-11-05, release date: 2004-03-23, Last modification date: 2020-07-29)

Primary citation

Stevens, J.,Corper, A.L.,Basler, C.F.,Taubenberger, J.K.,Palese, P.,Wilson, I.A.
Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus.
Science, 303:1866-1870, 2004

PubMed Abstract: The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.

PubMed: 14764887
DOI: 10.1126/science.1093373

Experimental method

X-RAY DIFFRACTION (3 Å)