1RD8

Crystal Structure of the 1918 Human H1 Hemagglutinin Precursor (HA0)

1RD8 の概要

• エントリーDOI: 10.2210/pdb1rd8/pdb
• 分子名称: hemagglutinin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: glycoprotein, membrane-fusion precursor, virus/viral protein, viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 176670.15

構造登録者

Stevens, J.,Corper, A.L.,Basler, C.F.,Taubenberger, J.K.,Palese, P.,Wilson, I.A. (登録日: 2003-11-05, 公開日: 2004-03-23, 最終更新日: 2024-11-20)

主引用文献

Stevens, J.,Corper, A.L.,Basler, C.F.,Taubenberger, J.K.,Palese, P.,Wilson, I.A.
Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus.
Science, 303:1866-1870, 2004

PubMed Abstract: The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.

PubMed: 14764887
DOI: 10.1126/science.1093373

実験手法

X-RAY DIFFRACTION (3 Å)