1RAO

CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI HPPK WITH AMP AND 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE AT 1.56 ANGSTROM RESOLUTION

1RAO の概要

• エントリーDOI: 10.2210/pdb1rao/pdb
• 関連するPDBエントリー: 1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ADENOSINE MONOPHOSPHATE, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: pyrophosphokinase, pyrophosphoryl transfer, catalytic mechanism, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, 6-hydroxymethylpterin, ternary complex, substrate specificity, product release, antimicrobial agent, drug design, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18666.88

構造登録者

Blaszczyk, J.,Ji, X. (登録日: 2003-10-31, 公開日: 2004-11-09, 最終更新日: 2023-08-30)

• 主引用文献: Blaszczyk, J.,Shi, G.,Li, Y.,Yan, H.,Ji, X.; Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.; Structure, 12:467-475, 2004; PubMed: 15016362; DOI: 10.1016/j.str.2004.02.003

実験手法

X-RAY DIFFRACTION (1.56 Å)