1R6U

Crystal structure of an active fragment of human tryptophanyl-tRNA synthetase with cytokine activity

Summary for 1R6U

• Entry DOI: 10.2210/pdb1r6u/pdb
• Related: 1N3L 1NTG 1R6T
• Descriptor: Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL, ... (4 entities in total)
• Functional Keywords: class ic trna synthetase, rossmann fold catalytic domain, anticodon recognition domain, bound trp-amp, ligase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P23381
• Total number of polymer chains: 2
• Total formula weight: 101033.81

Authors

Yang, X.-L.,Otero, F.J.,Skene, R.J.,McRee, D.E.,Ribas de Pouplana, L.,Schimmel, P. (deposition date: 2003-10-16, release date: 2004-01-06, Last modification date: 2021-10-27)

• Primary citation: Yang, X.-L.,Guo, M.,Kapoor, M.,Ewalt, K.L.,Otero, F.J.,Skene, R.J.,McRee, D.E.,Schimmel, P.; Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase; Structure, 15:793-805, 2007; PubMed: 17637340; DOI: 10.1016/j.str.2007.05.009

Experimental method

X-RAY DIFFRACTION (2 Å)