1R6G
Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound
Summary for 1R6G
Entry DOI | 10.2210/pdb1r6g/pdb |
Descriptor | Thyroid hormone receptor beta-1, 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL (2 entities in total) |
Functional Keywords | alpha helical, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 1 |
Total formula weight | 29826.16 |
Authors | Hangeland, J.J.,Dejneka, T.,Friends, T.J.,Devasthale, P.,Mellstrom, K.,Sandberg, J.,Grynfarb, M.,Doweyko, A.M.,Sack, J.S.,Einspahr, H.,Farnegardh, M.,Husman, B.,Ljunggren, J.,Koehler, K.,Sheppard, C.,Malm, J.,Ryono, D.E. (deposition date: 2003-10-15, release date: 2005-02-15, Last modification date: 2024-02-14) |
Primary citation | Hangeland, J.J.,Doweyko, A.M.,Dejneka, T.,Friends, T.J.,Devasthale, P.,Mellstrom, K.,Sandberg, J.,Grynfarb, M.,Sack, J.S.,Einspahr, H.,Farnegardh, M.,Husman, B.,Ljunggren, J.,Koehler, K.,Sheppard, C.,Malm, J.,Ryono, D.E. Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta. Bioorg.Med.Chem.Lett., 14:3549-3553, 2004 Cited by PubMed: 15177471DOI: 10.1016/j.bmcl.2004.04.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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