1R6A

Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate

1R6A の概要

• エントリーDOI: 10.2210/pdb1r6a/pdb
• 関連するPDBエントリー: 1L9K
• 分子名称: Genome polyprotein, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: ribavirin 5'-triphosphate, dengue virus, 2'o methyltransferase, transferase
• 由来する生物種: Dengue virus 2 Puerto Rico/PR159-S1/1969
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P12823
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34526.71

構造登録者

Benarroch, D.,Egloff, M.P.,Mulard, L.,Romette, J.L.,Canard, B. (登録日: 2003-10-15, 公開日: 2004-09-21, 最終更新日: 2024-02-14)

• 主引用文献: Benarroch, D.,Egloff, M.P.,Mulard, L.,Guerreiro, C.,Romette, J.L.,Canard, B.; A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.; J.Biol.Chem., 279:35638-35643, 2004; PubMed: 15152003; DOI: 10.1074/jbc.M400460200

実験手法

X-RAY DIFFRACTION (2.6 Å)