1R4E

Solution structure of the Complex Formed between a Left-Handed Wedge-Shaped Spirocyclic Molecule and Bulged DNA

Summary for 1R4E

• Entry DOI: 10.2210/pdb1r4e/pdb
• Related: 1P96
• Descriptor: 5'-D(*CP*AP*CP*GP*CP*AP*GP*TP*TP*CP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*GP*AP*TP*GP*CP*GP*TP*G)-3', SPIRO[NAPHTHALENE-2(3H),3'(10'H)-PENTALENO[1,2-B]NAPHTHALENE]-3,10'-DIONE, 2'-[(2-AMINO-2-DEOXY-B-D-GULOPYRANOSYL)OXY]-1,1',2',3'A,4,10'A-HEXAHYDRO-,(2'R,3'AS,10'AR)-(9CI) (3 entities in total)
• Functional Keywords: wedge-shaped spirocyclic enantiomer-bulged dna complex, dna
• Total number of polymer chains: 2
• Total formula weight: 8489.76

Authors

Hwang, G.S.,Jones, G.B.,Goldberg, I.H. (deposition date: 2003-10-06, release date: 2004-04-27, Last modification date: 2024-05-01)

• Primary citation: Hwang, G.S.,Jones, G.B.,Goldberg, I.H.; Stereochemical control of small molecule binding to bulged DNA: comparison of structures of spirocyclic enantiomer-bulged DNA complexes.; Biochemistry, 43:641-650, 2004; PubMed: 14730968; DOI: 10.1021/bi035824i

Experimental method

SOLUTION NMR