1R2B

Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide

1R2B の概要

• エントリーDOI: 10.2210/pdb1r2b/pdb
• 関連するPDBエントリー: 1R28 1R29
• 分子名称: B-cell lymphoma 6 protein, Nuclear receptor co-repressor 2 (3 entities in total)
• 機能のキーワード: btb domain, hdac complex, b-cell lymphoma, transcriptional repression, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus (By similarity): P41182; Nucleus: Q9Y618
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 33168.30

構造登録者

Ahmad, K.F.,Melnick, A.,Lax, S.A.,Bouchard, D.,Liu, J.,Kiang, C.L.,Mayer, S.,Licht, J.D.,Prive, G.G. (登録日: 2003-09-26, 公開日: 2003-12-23, 最終更新日: 2024-02-14)

主引用文献

Ahmad, K.F.,Melnick, A.,Lax, S.,Bouchard, D.,Liu, J.,Kiang, C.L.,Mayer, S.,Takahashi, S.,Licht, J.D.,Prive, G.G.
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.
Mol.Cell, 12:1551-1564, 2003

PubMed Abstract: BCL6 encodes a transcription factor that represses genes necessary for the terminal differentiation of lymphocytes within germinal centers, and the misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6 (also known as the POZ domain) is required for the repression activity of the protein and interacts directly with the SMRT and N-CoR corepressors that are found within large multiprotein histone deacetylase-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein.

PubMed: 14690607
DOI: 10.1016/S1097-2765(03)00454-4

実験手法

X-RAY DIFFRACTION (2.2 Å)