1QXZ

Crystal structure of S. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119

Summary for 1QXZ

Entry DOI	10.2210/pdb1qxz/pdb
Related	1QXW 1QXY
Descriptor	methionyl aminopeptidase, COBALT (II) ION, (2S)-2-AMINO-4-(METHYLSULFANYL)-1-(1,3-THIAZOL-2-YL)BUTANE-1,1-DIOL, ... (4 entities in total)
Functional Keywords	pita bread fold, hydrolase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	27946.39
Authors	Douangamath, A.,Dale, G.E.,D'Arcy, A.,Oefner, C. (deposition date: 2003-09-09, release date: 2004-03-16, Last modification date: 2024-02-14)
Primary citation	Douangamath, A.,Dale, G.E.,D'Arcy, A.,Almstetter, M.,Eckl, R.,Frutos-Hoener, A.,Henkel, B.,Illgen, K.,Nerdinger, S.,Schulz, H.,MacSweeney, A.,Thormann, M.,Treml, A.,Pierau, S.,Wadman, S.,Oefner, C. Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate. J.Med.Chem., 47:1325-1328, 2004 Cited by PubMed: 14998322 DOI: 10.1021/jm034188j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation