1QWC

Rat neuronal nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.

Summary for 1QWC

Related1QW4 1QW5 1QW6
DescriptorNitric-oxide synthase, brain, ZINC ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywordsrat nnosoxy w1400 inhibitor complex, oxidoreductase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein  P29476
Total number of polymer chains1
Total molecular weight49680.59
Authors
Fedorov, R.,Hartmann, E.,Ghosh, D.K.,Schlichting, I. (deposition date: 2003-09-02, release date: 2003-12-09, Last modification date: 2017-10-11)
Primary citation
Fedorov, R.,Hartmann, E.,Ghosh, D.K.,Schlichting, I.
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms.
J.Biol.Chem., 278:45818-45825, 2003
PubMed: 12954642 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M306030200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22524 1.9% 8.0% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02