1QS4

Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone

1QS4 の概要

• エントリーDOI: 10.2210/pdb1qs4/pdb
• 分子名称: PROTEIN (HIV-1 INTEGRASE (E.C.2.7.7.49)), MAGNESIUM ION, 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)-PROPENONE, ... (4 entities in total)
• 機能のキーワード: dna integration, integrase, hiv, aspartyl protease, endonuclease, transferase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50802.25

構造登録者

Goldgur, Y.,Craigie, R.,Fujiwara, T.,Yoshinaga, T.,Davies, D.R. (登録日: 1999-06-25, 公開日: 1999-11-17, 最終更新日: 2024-02-14)

• 主引用文献: Goldgur, Y.,Craigie, R.,Cohen, G.H.,Fujiwara, T.,Yoshinaga, T.,Fujishita, T.,Sugimoto, H.,Endo, T.,Murai, H.,Davies, D.R.; Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design.; Proc.Natl.Acad.Sci.USA, 96:13040-13043, 1999; PubMed: 10557269; DOI: 10.1073/pnas.96.23.13040

実験手法

X-RAY DIFFRACTION (2.1 Å)