1QRP

Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME

1QRP の概要

• エントリーDOI: 10.2210/pdb1qrp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000657
• 分子名称: PEPSIN 3A, methyl N-[(2S)-2-({(S)-hydroxy[(1R)-3-methyl-1-{[N-(3-methylbutanoyl)-L-valyl-L-valyl]amino}butyl]phosphoryl}oxy)-3-phenylpropanoyl]-L-alanyl-L-alaninate (3 entities in total)
• 機能のキーワード: aspartic proteinase, phosphonate inhibitor, transition state analogue, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35385.75

構造登録者

Fujinaga, M.,Cherney, M.M.,Tarasova, N.I.,Bartlett, P.A.,Hanson, J.E.,James, M.N.G. (登録日: 1999-06-15, 公開日: 1999-06-18, 最終更新日: 2012-12-12)

• 主引用文献: Fujinaga, M.,Cherney, M.M.,Tarasova, N.I.,Bartlett, P.A.,Hanson, J.E.,James, M.N.; Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.; Acta Crystallogr.,Sect.D, 56:272-279, 2000; PubMed: 10713513; DOI: 10.1107/S0907444999016376

実験手法

X-RAY DIFFRACTION (1.96 Å)