1QPD

STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

1QPD の概要

• エントリーDOI: 10.2210/pdb1qpd/pdb
• 関連するPDBエントリー: 1QPC 1QPE 1QPJ
• 分子名称: LCK KINASE, SULFATE ION, STAUROSPORINE, ... (4 entities in total)
• 機能のキーワード: alpha beta fold, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32739.26

構造登録者

Zhu, X.,Kim, J.L.,Rose, P.E.,Stover, D.R.,Toledo, L.M.,Zhao, H.,Morgenstern, K.A. (登録日: 1999-05-24, 公開日: 2000-05-24, 最終更新日: 2024-11-20)

主引用文献

Zhu, X.,Kim, J.L.,Newcomb, J.R.,Rose, P.E.,Stover, D.R.,Toledo, L.M.,Zhao, H.,Morgenstern, K.A.
Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Structure Fold.Des., 7:651-661, 1999

PubMed Abstract: The lymphocyte-specific kinase Lck is a member of the Src family of non-receptor tyrosine kinases. Lck catalyzes the initial phosphorylation of T-cell receptor components that is necessary for signal transduction and T-cell activation. On the basis of both biochemical and genetic studies, Lck is considered an attractive cell-specific target for the design of novel T-cell immunosuppressants. To date, the lack of detailed structural information on the mode of inhibitor binding to Lck has limited the discovery of novel Lck inhibitors.

PubMed: 10404594
DOI: 10.1016/S0969-2126(99)80086-0

実験手法

X-RAY DIFFRACTION (2 Å)