1QNZ

NMR structure of the 0.5b anti-HIV antibody complex with the gp120 V3 peptide

Summary for 1QNZ

• Entry DOI: 10.2210/pdb1qnz/pdb
• Descriptor: 0.5B ANTIBODY (HEAVY CHAIN), 0.5B ANTIBODY (LIGHT CHAIN), GP120 (3 entities in total)
• Functional Keywords: antibody, v3 peptide, binding site, immune system
• Biological source: MUS MUSCULUS (HOUSE MOUSE); More
• Cellular location: Virion membrane : Q79416
• Total number of polymer chains: 3
• Total formula weight: 27608.65

Authors

Tugarinov, V.,Zvi, A.,Levy, R.,Hayek, Y.,Matsushita, S.,Anglister, J. (deposition date: 1999-10-26, release date: 2000-06-03, Last modification date: 2024-11-06)

Primary citation

Tugarinov, V.,Zvi, A.,Levy, R.,Hayek, Y.,Matsushita, S.,Anglister, J.
NMR Structure of an Anti-Gp120 Antibody Complex with a V3 Peptide Reveals a Surface Important for Co-Receptor Binding
Structure, 8:385-395, 2000

PubMed Abstract: The protein 0.5beta is a potent strain-specific human immunodeficiency virus type 1 (HIV-1) neutralizing antibody raised against the entire envelope glycoprotein (gp120) of the HIV-1(IIIB) strain. The epitope recognized by 0.5beta is located within the third hypervariable region (V3) of gp120. Recently, several HIV-1 V3 residues involved in co-receptor utilization and selection were identified.

PubMed: 10801487
DOI: 10.1016/S0969-2126(00)00119-2

Experimental method

SOLUTION NMR