1QMI

Crystal structure of RNA 3'-terminal phosphate cyclase, an ubiquitous enzyme with unusual topology

1QMI の概要

• エントリーDOI: 10.2210/pdb1qmi/pdb
• 関連するPDBエントリー: 1QMH
• 分子名称: RNA 3'-TERMINAL PHOSPHATE CYCLASE (1 entity in total)
• 機能のキーワード: ligase, 2'3'cyclic phosphate rna
• 由来する生物種: ESCHERICHIA COLI
• 細胞内の位置: Cytoplasm: P46849
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 148994.81

構造登録者

Palm, G.J.,Billy, E.,Filipowicz, W.,Wlodawer, A. (登録日: 1999-09-28, 公開日: 2000-01-11, 最終更新日: 2013-04-17)

主引用文献

Palm, G.J.,Billy, E.,Filipowicz, W.,Wlodawer, A.
Crystal Structure of RNA 3'-Terminal Phosphate Cyclase, a Ubiquitous Enzyme with Unusual Topology
Structure, 8:13-, 2000

PubMed Abstract: RNA cyclases are a family of RNA-modifying enzymes that are conserved in eucarya, bacteria and archaea. They catalyze the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate. These enzymes might be responsible for production of the cyclic phosphate RNA ends that are known to be required by many RNA ligases in both prokaryotes and eukaryotes.

PubMed: 10673421
DOI: 10.1016/S0969-2126(00)00076-9

実験手法

X-RAY DIFFRACTION (2.8 Å)