1QFF

E. COLI FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) IN COMPLEX WITH BOUND FERRICHROME-IRON

Summary for 1QFF

• Entry DOI: 10.2210/pdb1qff/pdb
• Related: 1QFG
• Descriptor: FERRIC HYDROXAMATE UPTAKE RECEPTOR, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, alpha-D-glucopyranose-(1-3)-[alpha-D-galactopyranose-(1-6)]alpha-D-glucopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2,3-dideoxy-alpha-D-glucoyranose-(1-6)-2-amino-2-deoxy-alpha-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: tonb-dependent receptor, integral outer membrane protein, siderophore-iron receptor, active transport, lipopolysaccharide, ferrichrome receptor, metal transport
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 85237.85

Authors

Ferguson, A.D.,Hofmann, E.,Coulton, J.W.,Diederichs, K.,Welte, W. (deposition date: 1999-04-10, release date: 2000-07-26, Last modification date: 2024-10-30)

Primary citation

Ferguson, A.D.,Welte, W.,Hofmann, E.,Lindner, B.,Holst, O.,Coulton, J.W.,Diederichs, K.
A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins.
Structure Fold.Des., 8:585-592, 2000

PubMed Abstract: Lipopolysaccharide (LPS), a lipoglycan from the outer membrane of Gram-negative bacteria, is an immunomodulatory molecule that stimulates the innate immune response. High levels of LPS cause excessive release of inflammatory mediators and are responsible for the septic shock syndrome. The interaction of LPS with its cognate binding proteins has not, as yet, been structurally elucidated.

PubMed: 10873859
DOI: 10.1016/S0969-2126(00)00143-X

Experimental method

X-RAY DIFFRACTION (2.7 Å)