1Q1M
A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors
Summary for 1Q1M
Entry DOI | 10.2210/pdb1q1m/pdb |
Related | 1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein tyrosine phosphatase 1b, ptp1b, inhibitors with isoxazole-salicylate pharmacophores, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 37778.99 |
Authors | Liu, G.,Xin, Z.,Pei, Z.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Zhao, H.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. (deposition date: 2003-07-22, release date: 2003-09-16, Last modification date: 2023-08-16) |
Primary citation | Liu, G.,Xin, Z.,Pei, Z.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Zhao, H.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J.Med.Chem., 46:4232-4235, 2003 Cited by PubMed: 13678400DOI: 10.1021/jm034122o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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