1PXX
CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Summary for 1PXX
Entry DOI | 10.2210/pdb1pxx/pdb |
Related | 1CVU 6COX |
Related PRD ID | PRD_900017 |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | cox-2, cyclooxygenase, prostaglandin, diclofenac, endoperoxide, oxidoreductase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 4 |
Total formula weight | 284886.98 |
Authors | Kiefer, J.R.,Rowlinson, S.W.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Marnett, L.J.,Kurumbail, R.G. (deposition date: 2003-07-07, release date: 2003-09-09, Last modification date: 2020-07-29) |
Primary citation | Rowlinson, S.W.,Kiefer, J.R.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Kurumbail, R.G.,Marnett, L.J. A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385. J.Biol.Chem., 278:45763-45769, 2003 Cited by PubMed: 12925531DOI: 10.1074/jbc.M305481200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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