1PXX

CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

1PXX の概要

• エントリーDOI: 10.2210/pdb1pxx/pdb
• 関連するPDBエントリー: 1CVU 6COX
• 関連するBIRD辞書のPRD_ID: PRD_900017
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: cox-2, cyclooxygenase, prostaglandin, diclofenac, endoperoxide, oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 284886.98

構造登録者

Kiefer, J.R.,Rowlinson, S.W.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Marnett, L.J.,Kurumbail, R.G. (登録日: 2003-07-07, 公開日: 2003-09-09, 最終更新日: 2020-07-29)

• 主引用文献: Rowlinson, S.W.,Kiefer, J.R.,Prusakiewicz, J.J.,Pawlitz, J.L.,Kozak, K.R.,Kalgutkar, A.S.,Stallings, W.C.,Kurumbail, R.G.,Marnett, L.J.; A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385.; J.Biol.Chem., 278:45763-45769, 2003; PubMed: 12925531; DOI: 10.1074/jbc.M305481200

実験手法

X-RAY DIFFRACTION (2.9 Å)