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1PVL

STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN F COMPONENT FROM STAPHYLOCOCCUS AUREUS

Summary for 1PVL
Entry DOI10.2210/pdb1pvl/pdb
DescriptorLEUCOCIDIN, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
Functional Keywordsbi-component leucotoxin, transmembrane pore, leucotoxin
Biological sourceStaphylococcus aureus
Total number of polymer chains1
Total formula weight34884.51
Authors
Pedelacq, J.D.,Mourey, L.,Maveyraud, L.,Prevost, G.,Samama, J.P. (deposition date: 1999-01-12, release date: 1999-06-15, Last modification date: 2024-02-14)
Primary citationPedelacq, J.D.,Maveyraud, L.,Prevost, G.,Baba-Moussa, L.,Gonzalez, A.,Courcelle, E.,Shepard, W.,Monteil, H.,Samama, J.P.,Mourey, L.
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
Structure Fold.Des., 7:277-287, 1999
Cited by
PubMed Abstract: Leucocidins and gamma-hemolysins are bi-component toxins secreted by Staphylococcus aureus. These toxins activate responses of specific cells and form lethal transmembrane pores. Their leucotoxic and hemolytic activities involve the sequential binding and the synergistic association of a class S and a class F component, which form hetero-oligomeric complexes. The components of each protein class are produced as non-associated, water-soluble proteins that undergo conformational changes and oligomerization after recognition of their cell targets.
PubMed: 10368297
DOI: 10.1016/S0969-2126(99)80038-0
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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