1PVL

STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN F COMPONENT FROM STAPHYLOCOCCUS AUREUS

Summary for 1PVL

• Entry DOI: 10.2210/pdb1pvl/pdb
• Descriptor: LEUCOCIDIN, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: bi-component leucotoxin, transmembrane pore, leucotoxin
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 1
• Total formula weight: 34884.51

Authors

Pedelacq, J.D.,Mourey, L.,Maveyraud, L.,Prevost, G.,Samama, J.P. (deposition date: 1999-01-12, release date: 1999-06-15, Last modification date: 2024-02-14)

Primary citation

Pedelacq, J.D.,Maveyraud, L.,Prevost, G.,Baba-Moussa, L.,Gonzalez, A.,Courcelle, E.,Shepard, W.,Monteil, H.,Samama, J.P.,Mourey, L.
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
Structure Fold.Des., 7:277-287, 1999

PubMed Abstract: Leucocidins and gamma-hemolysins are bi-component toxins secreted by Staphylococcus aureus. These toxins activate responses of specific cells and form lethal transmembrane pores. Their leucotoxic and hemolytic activities involve the sequential binding and the synergistic association of a class S and a class F component, which form hetero-oligomeric complexes. The components of each protein class are produced as non-associated, water-soluble proteins that undergo conformational changes and oligomerization after recognition of their cell targets.

PubMed: 10368297
DOI: 10.1016/S0969-2126(99)80038-0

Experimental method

X-RAY DIFFRACTION (2 Å)