1PVL
STRUCTURE OF THE PANTON-VALENTINE LEUCOCIDIN F COMPONENT FROM STAPHYLOCOCCUS AUREUS
Summary for 1PVL
Entry DOI | 10.2210/pdb1pvl/pdb |
Descriptor | LEUCOCIDIN, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total) |
Functional Keywords | bi-component leucotoxin, transmembrane pore, leucotoxin |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 34884.51 |
Authors | Pedelacq, J.D.,Mourey, L.,Maveyraud, L.,Prevost, G.,Samama, J.P. (deposition date: 1999-01-12, release date: 1999-06-15, Last modification date: 2024-02-14) |
Primary citation | Pedelacq, J.D.,Maveyraud, L.,Prevost, G.,Baba-Moussa, L.,Gonzalez, A.,Courcelle, E.,Shepard, W.,Monteil, H.,Samama, J.P.,Mourey, L. The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins. Structure Fold.Des., 7:277-287, 1999 Cited by PubMed Abstract: Leucocidins and gamma-hemolysins are bi-component toxins secreted by Staphylococcus aureus. These toxins activate responses of specific cells and form lethal transmembrane pores. Their leucotoxic and hemolytic activities involve the sequential binding and the synergistic association of a class S and a class F component, which form hetero-oligomeric complexes. The components of each protein class are produced as non-associated, water-soluble proteins that undergo conformational changes and oligomerization after recognition of their cell targets. PubMed: 10368297DOI: 10.1016/S0969-2126(99)80038-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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