1PRO

HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881

1PRO の概要

• エントリーDOI: 10.2210/pdb1pro/pdb
• 分子名称: HIV-1 PROTEASE, (5R,6R)-2,4-BIS-(4-HYDROXY-3-METHOXYBENZYL)-1,5-DIBENZYL-3-OXO-6-HYDROXY-1,2,4-TRIAZACYCLOHEPTANE (3 entities in total)
• 機能のキーワード: aids, polyprotein, hydrolase, aspartic protease, endonuclease, rna-directed dna polymerase, hydrolase (aspartic protease)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22245.24

構造登録者

Park, C.H.,Kong, X.P.,Dealwis, C.G. (登録日: 1995-07-18, 公開日: 1996-08-17, 最終更新日: 2024-02-14)

• 主引用文献: Sham, H.L.,Zhao, C.,Stewart, K.D.,Betebenner, D.A.,Lin, S.,Park, C.H.,Kong, X.P.,Rosenbrook Jr., W.,Herrin, T.,Madigan, D.,Vasavanonda, S.,Lyons, N.,Molla, A.,Saldivar, A.,Marsh, K.C.,McDonald, E.,Wideburg, N.E.,Denissen, J.F.,Robins, T.,Kempf, D.J.,Plattner, J.J.,Norbeck, D.W.; A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.; J.Med.Chem., 39:392-397, 1996; PubMed: 8558507; DOI: 10.1021/jm9507183

実験手法

X-RAY DIFFRACTION (1.8 Å)