1PRO

HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881

1PRO の概要

分子名称HIV-1 PROTEASE, (5R,6R)-2,4-BIS-(4-HYDROXY-3-METHOXYBENZYL)-1,5-DIBENZYL-3-OXO-6-HYDROXY-1,2,4-TRIAZACYCLOHEPTANE (3 entities in total)
機能のキーワードaids, polyprotein, hydrolase, aspartic protease, endonuclease, rna-directed dna polymerase, hydrolase (aspartic protease)
由来する生物種Human immunodeficiency virus 1
細胞内の位置Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P12499
ポリマー鎖数2
分子量合計22245.24
構造登録者
Park, C.H.,Kong, X.P.,Dealwis, C.G. (登録日: 1995-07-18, 公開日: 1996-08-17, 最終更新日: 2011-07-13)
主引用文献
Sham, H.L.,Zhao, C.,Stewart, K.D.,Betebenner, D.A.,Lin, S.,Park, C.H.,Kong, X.P.,Rosenbrook Jr., W.,Herrin, T.,Madigan, D.,Vasavanonda, S.,Lyons, N.,Molla, A.,Saldivar, A.,Marsh, K.C.,McDonald, E.,Wideburg, N.E.,Denissen, J.F.,Robins, T.,Kempf, D.J.,Plattner, J.J.,Norbeck, D.W.
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
J.Med.Chem., 39:392-397, 1996
PubMed: 8558507 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm9507183
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.8 Å)
?

構造検証レポート

ClashscoreRamachandran outliersSidechain outliers408.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード