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1POB

CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE

Summary for 1POB
Entry DOI10.2210/pdb1pob/pdb
DescriptorPHOSPHOLIPASE A2, CALCIUM ION, 1-O-OCTYL-2-HEPTYLPHOSPHONYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceNaja atra (Chinese cobra)
Total number of polymer chains2
Total formula weight27448.64
Authors
White, S.P.,Scott, D.L.,Otwinowski, Z.,Sigler, P.B. (deposition date: 1992-09-07, release date: 1993-10-31, Last modification date: 2024-12-25)
Primary citationWhite, S.P.,Scott, D.L.,Otwinowski, Z.,Gelb, M.H.,Sigler, P.B.
Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue.
Science, 250:1560-1563, 1990
Cited by
PubMed Abstract: The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is stabilized and how the hydrophobic fatty acyl chains of the substrate are accommodated by the enzyme during interfacial catalysis. The critical features that suggest the chemistry of binding and catalysis are the same as those seen in the crystal structure of a similar complex formed with the evolutionarily distant bee-venom PLA2.
PubMed: 2274787
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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