1POB
CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005102 | molecular_function | signaling receptor binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 0050482 | biological_process | arachidonate secretion |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 801 |
| Chain | Residue |
| A | TYR27 |
| A | GLY29 |
| A | GLY31 |
| A | ASP48 |
| A | GEL930 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 802 |
| Chain | Residue |
| B | TYR27 |
| B | GLY29 |
| B | GLY31 |
| B | ASP48 |
| B | GEL935 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 803 |
| Chain | Residue |
| A | TYR24 |
| A | GLY25 |
| A | CYS28 |
| A | HOH429 |
| A | HOH709 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 804 |
| Chain | Residue |
| B | TYR24 |
| B | GLY25 |
| B | CYS28 |
| B | HOH481 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GEL A 930 |
| Chain | Residue |
| A | LEU2 |
| A | TRP18 |
| A | PHE21 |
| A | TYR27 |
| A | GLY29 |
| A | ARG30 |
| A | GLY31 |
| A | CYS44 |
| A | HIS47 |
| A | ASP48 |
| A | ASN52 |
| A | TYR63 |
| A | HOH421 |
| A | HOH711 |
| A | CA801 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GEL B 935 |
| Chain | Residue |
| B | LEU2 |
| B | LEU2 |
| B | LYS6 |
| B | ILE9 |
| B | TRP18 |
| B | TYR27 |
| B | GLY29 |
| B | GLY31 |
| B | CYS44 |
| B | HIS47 |
| B | ASP48 |
| B | TYR51 |
| B | ASN52 |
| B | TYR63 |
| B | TYR63 |
| B | PHE64 |
| B | CA802 |
| site_id | CA1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | CYS28 |
| A | ARG30 |
| A | GLY32 |
| A | ASN49 |
| site_id | CA2 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| A | TYR24 |
| A | GLY25 |
| A | CYS28 |
| site_id | CA3 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| B | GLY32 |
| B | ASN49 |
| B | CYS28 |
| B | ARG30 |
| site_id | CA4 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| B | TYR24 |
| B | GLY25 |
| B | CYS28 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"2274785","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"2274785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2274787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1POA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1POB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS47 | |
| A | ASP93 | |
| A | GLY29 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| B | HIS47 | |
| B | ASP93 | |
| B | GLY29 |
