1PO6

Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)

Summary for 1PO6

• Entry DOI: 10.2210/pdb1po6/pdb
• Descriptor: 5'-D(*T*AP*GP*GP*(6MI)P*TP*TP*AP*GP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein A1 (3 entities in total)
• Functional Keywords: protein-dna complex, up1, human telomeric repeat, htr, tr2-6f, rrm, rna recognition motif, 6mi, 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine, hnrnp a1, rna binding protein-dna complex, rna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P09651
• Total number of polymer chains: 2
• Total formula weight: 24392.83

Authors

Myers, J.C.,Moore, S.A.,Shamoo, Y. (deposition date: 2003-06-13, release date: 2003-11-11, Last modification date: 2023-08-16)

• Primary citation: Myers, J.C.,Moore, S.A.,Shamoo, Y.; Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures; J.BIOL.CHEM., 278:42300-42306, 2003; PubMed: 12904298; DOI: 10.1074/jbc.M306147200

Experimental method

X-RAY DIFFRACTION (2.1 Å)