1PI5

Structure of N289A mutant of AmpC in complex with SM2, carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain

Summary for 1PI5

• Entry DOI: 10.2210/pdb1pi5/pdb
• Related: 1MXO 1MY8
• Descriptor: Beta-lactamase, PHOSPHATE ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: enzyme inhibitor complex, beta-lactamase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 80220.39

Authors

Roth, T.A.,Minasov, G.,Focia, P.J.,Shoichet, B.K. (deposition date: 2003-05-29, release date: 2004-02-24, Last modification date: 2023-08-16)

• Primary citation: Roth, T.A.,Minasov, G.,Morandi, S.,Prati, F.,Shoichet, B.K.; Thermodynamic cycle analysis and inhibitor design against beta-lactamase.; Biochemistry, 42:14483-14491, 2003; PubMed: 14661960; DOI: 10.1021/bi035054a

Experimental method

X-RAY DIFFRACTION (1.49 Å)