1PBO

COMPLEX OF BOVINE ODORANT BINDING PROTEIN (OBP) WITH A SELENIUM CONTAINING ODORANT

Summary for 1PBO

• Entry DOI: 10.2210/pdb1pbo/pdb
• Descriptor: ODORANT BINDING PROTEIN, 4-butyl-5-propyl-1,3-selenazol-2-amine (3 entities in total)
• Functional Keywords: odorant-binding, transport, lipocalin
• Biological source: Bos taurus (cattle)
• Cellular location: Secreted: P07435
• Total number of polymer chains: 2
• Total formula weight: 37461.21

Authors

Amzel, L.M.,Bianchet, M.A.,Monaco, H.,Bains, G. (deposition date: 1996-07-15, release date: 1997-07-23, Last modification date: 2024-02-14)

Primary citation

Bianchet, M.A.,Bains, G.,Pelosi, P.,Pevsner, J.,Snyder, S.H.,Monaco, H.L.,Amzel, L.M.
The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition.
Nat.Struct.Biol., 3:934-939, 1996

PubMed Abstract: Odorant binding protein (OBP) is the major odorant binding component of mammalian nasal mucosa. The two structures of bovine OBP reported in this paper (one crystallized as purified and one soaked in the presence of a selenium-containing odorant) show that: (i) the OBP dimer is composed of two compact domains related by an approximate two-fold axis of symmetry; (ii) between residues 122 and 123 the polypeptide chains cross from one domain to the other such that each domain is formed by residues from both monomers; (iii) purified OBP already contains two bound odorant molecules (one per monomer)-odorant binding occurs by replacement of these molecules with the added odorant; and (iv) the structure of the odorant binding site can explain OBP's extraordinarily broad odorant specificity.

PubMed: 8901871
DOI: 10.1038/nsb1196-934

Experimental method

X-RAY DIFFRACTION (2.2 Å)