1OZN

1.5A Crystal Structure of the Nogo Receptor Ligand Binding Domain Reveals a Convergent Recognition Scaffold Mediating Inhibition of Myelination

1OZN の概要

• エントリーDOI: 10.2210/pdb1ozn/pdb
• 分子名称: Reticulon 4 receptor, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: nogo receptor, mad, myelination inhibition, omgp, mag, nogo-66, p75, signal transduction, neuronal regeneration, ligand binding, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Lipid-anchor, GPI-anchor: Q9BZR6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33128.76

構造登録者

He, X.,Bazan, J.F.,Park, J.B.,McDermott, G.,He, Z.,Garcia, K.C. (登録日: 2003-04-09, 公開日: 2003-05-20, 最終更新日: 2020-07-29)

• 主引用文献: He, X.L.,Bazan, J.F.,McDermott, G.,Park, J.B.,Wang, K.,Tessier-Lavigne, M.,He, Z.,Garcia, K.C.; Structure of the Nogo Receptor Ectodomain. A Recognition module implicated in Myelin Inhibition.; Neuron, 38:177-185, 2003; PubMed: 12718853; DOI: 10.1016/S0896-6273(03)00232-0

実験手法

X-RAY DIFFRACTION (1.52 Å)