1OWE
Substituted 2-Naphthamidine inhibitors of urokinase
Summary for 1OWE
Entry DOI | 10.2210/pdb1owe/pdb |
Related | 1FV9 1OWD 1OWH 1OWI 1OWJ 1OWK |
Descriptor | Urokinase-type plasminogen activator, SULFATE ION, 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE, ... (4 entities in total) |
Functional Keywords | plasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 1 |
Total formula weight | 28214.04 |
Authors | Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L. (deposition date: 2003-03-28, release date: 2003-09-30, Last modification date: 2017-10-11) |
Primary citation | Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L. Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution. J.Med.Chem., 47:303-324, 2004 Cited by PubMed: 14711304DOI: 10.1021/jm0300072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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