1ORW

Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor

1ORW の概要

• エントリーDOI: 10.2210/pdb1orw/pdb
• 関連するPDBエントリー: 1ORV
• 分子名称: dipeptidyl peptidase IV, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: serine protease, oxyanion hole, substrate channeling, drug design, diabetes mellitus, hydrolase
• 由来する生物種: Sus scrofa (pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 347128.38

構造登録者

Engel, M.,Hoffmann, T.,Wagner, L.,Wermann, M.,Heiser, U.,Kiefersauer, R.,Huber, R.,Bode, W.,Demuth, H.U.,Brandstetter, H. (登録日: 2003-03-16, 公開日: 2003-05-06, 最終更新日: 2020-07-29)

• 主引用文献: Engel, M.,Hoffmann, T.,Wagner, L.,Wermann, M.,Heiser, U.,Kiefersauer, R.,Huber, R.,Bode, W.,Demuth, H.U.,Brandstetter, H.; The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism; Proc.Natl.Acad.Sci.USA, 100:5063-5068, 2003; PubMed: 12690074; DOI: 10.1073/pnas.0230620100

実験手法

X-RAY DIFFRACTION (2.84 Å)