1OPL
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Summary for 1OPL
Entry DOI | 10.2210/pdb1opl/pdb |
Related | 1OPJ 1OPK |
Descriptor | proto-oncogene tyrosine-protein kinase, MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE (3 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 2 |
Total formula weight | 123122.28 |
Authors | Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2003-03-06, release date: 2003-04-08, Last modification date: 2023-08-16) |
Primary citation | Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112:859-871, 2003 Cited by PubMed: 12654251DOI: 10.1016/S0092-8674(03)00194-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.42 Å) |
Structure validation
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