1OPL
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | proto-oncogene tyrosine-protein kinase | polymer | 537 | 61019.7 | 2 | UniProt (P00519) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | |
| 2 | C (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 3 | D, E (A, B) | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 427.3 | 2 | Chemie (P16) |
Sequence modifications
A, B: 1 - 531 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Arg 29 | Lys 29 | engineered mutation |
| Asp 30 | Glu 30 | engineered mutation |
| Asn 382 | Asp 382 | engineered mutation |
| Glu 532 | - | cloning artifact |
| Asn 533 | - | cloning artifact |
| Leu 534 | - | cloning artifact |
| Tyr 535 | - | cloning artifact |
| Phe 536 | - | cloning artifact |
| Gln 537 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122039.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1082.9 | |
| All* | Total formula weight | 123122.3 |
