1OO6

Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN23862

Summary for 1OO6

Entry DOI	10.2210/pdb1oo6/pdb
Related	1IDT 1OO5 1OON 1OOQ
Descriptor	Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 5-[BIS-2(CHLORO-ETHYL)-AMINO]-2,4-DINTRO-BENZAMIDE, ... (4 entities in total)
Functional Keywords	nad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, sn23862, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	49489.34
Authors	Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2003-03-03, release date: 2003-04-08, Last modification date: 2023-08-16)
Primary citation	Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form J.Med.Chem., 46:4009-4020, 2003 Cited by PubMed: 12954054 DOI: 10.1021/jm030843b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation