1OO5

Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs

Summary for 1OO5

Entry DOI	10.2210/pdb1oo5/pdb
Related	1IDT
Descriptor	Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE (3 entities in total)
Functional Keywords	nad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	48787.05
Authors	Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2003-03-03, release date: 2003-04-08, Last modification date: 2023-08-16)
Primary citation	Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form J.Med.Chem., 46:4009-4020, 2003 Cited by PubMed: 12954054 DOI: 10.1021/jm030843b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation