1OO5

Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Oxygen-insensitive NAD(P)H nitroreductase	polymer	217	23937.2	2	UniProt (P38489) Pfam (PF00881)	Escherichia coli	FMN-DEPENDENT NITROREDUCTASE, Dihydropteridine reductase
2	C, D (A, B)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	2	Chemie (FMN)
3	E, F (A, B)	water	water		18.0	64	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47874.4
Non-Polymers*	Number of molecules	2
	Total formula weight	912.7
All*	Total formula weight	48787.1

*Water molecules are not included.