1ONP

IspC complex with Mn2+ and fosmidomycin

Summary for 1ONP

• Entry DOI: 10.2210/pdb1onp/pdb
• Related: 1ONN 1ONO
• Descriptor: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, MANGANESE (II) ION, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, ... (4 entities in total)
• Functional Keywords: isoprenoid biosynthesis, mevalonate-independent pathway, ispc, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 87339.83

Authors

Steinbacher, S.,Kaiser, J.,Eisenreich, W.,Huber, R.,Bacher, A.,Rohdich, F. (deposition date: 2003-02-28, release date: 2003-03-18, Last modification date: 2023-10-25)

• Primary citation: Steinbacher, S.,Kaiser, J.,Eisenreich, W.,Huber, R.,Bacher, A.,Rohdich, F.; Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development.; J.BIOL.CHEM., 278:18401-18407, 2003; PubMed: 12621040; DOI: 10.1074/jbc.M300993200

Experimental method

X-RAY DIFFRACTION (2.5 Å)