1OKE

Crystal structure of the dengue 2 virus envelope protein in complex with n-octyl-beta-D-glucoside

「1OAM」から置き換えられました

1OKE の概要

• エントリーDOI: 10.2210/pdb1oke/pdb
• 関連するPDBエントリー: 1L9K 1OAM 1OAN 1OK8
• 分子名称: MAJOR ENVELOPE PROTEIN E, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: viral protein, membrane fusion, flavivirus, fusion peptide, low-ph conformational change, class 2 fusion protein
• 由来する生物種: DENGUE VIRUS TYPE 2
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P12823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90131.30

構造登録者

Modis, Y.,Harrison, S.C. (登録日: 2003-07-22, 公開日: 2003-07-24, 最終更新日: 2020-07-29)

• 主引用文献: Modis, Y.,Ogata, S.,Clements, D.,Harrison, S.C.; A Ligand-Binding Pocket in the Dengue Virus Envelope Glycoprotein.; Proc.Natl.Acad.Sci.USA, 100:6986-, 2003; PubMed: 12759475; DOI: 10.1073/PNAS.0832193100

実験手法

X-RAY DIFFRACTION (2.4 Å)