1OI1
Crystal Structure of the MBT domains of Human SCML2
Summary for 1OI1
| Entry DOI | 10.2210/pdb1oi1/pdb |
| Descriptor | SCML2 PROTEIN, DI(HYDROXYETHYL)ETHER (3 entities in total) |
| Functional Keywords | mbt, scml2 |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Nucleus : Q9UQR0 |
| Total number of polymer chains | 1 |
| Total formula weight | 24756.94 |
| Authors | Sathyamurthy, A.,Allen, M.D.,Murzin, A.G.,Bycroft, M. (deposition date: 2003-06-04, release date: 2003-06-15, Last modification date: 2024-05-08) |
| Primary citation | Sathyamurthy, A.,Allen, M.D.,Murzin, A.G.,Bycroft, M. Crystal Structure of the Malignant Brain Tumor (Mbt) Repeats in Sex Comb on Midleg-Like 2 (Scml2). J.Biol.Chem., 278:46968-, 2003 Cited by PubMed Abstract: Sex Comb on Midleg (SCM) belongs to the Polycomb group of proteins, which are involved in transcriptional regulation in Drosophila. It is one of the components of Polycomb repressive complex 1, a multiprotein complex of Polycomb group proteins involved in the maintenance of repression and the blocking of chromatin remodeling. SCM contains two approximately 100-residue malignant brain tumor (MBT) repeats at the N terminus. These repeats are also found in other proteins involved in transcriptional repression. Here, we report the 1.78-A crystal structure of the two MBT repeats of SCM-like 2 (SCML2), a human homologue of SCM. Each repeat consists of an extended arm and a beta-barrel core. There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains. PubMed: 12952983DOI: 10.1074/JBC.M306469200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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