1OFM

CRYSTAL STRUCTURE OF CHONDROITINASE B COMPLEXED TO CHONDROITIN 4-SULFATE TETRASACCHARIDE

Summary for 1OFM

• Entry DOI: 10.2210/pdb1ofm/pdb
• Related: 1DBG 1DBO 1OFL
• Descriptor: CHONDROITINASE B, alpha-D-galactopyranose-(1-3)-[beta-D-glucopyranose-(1-4)]2-O-methyl-alpha-L-fucopyranose-(1-4)-beta-D-xylopyranose-(1-4)-alpha-D-glucopyranuronic acid-(1-2)-[alpha-L-rhamnopyranose-(1-4)]alpha-D-mannopyranose, 4-deoxy-alpha-L-threo-hex-4-enopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose, ... (4 entities in total)
• Functional Keywords: active site, beta-elimination, chondroitin 4-sulfate, lyase
• Biological source: PEDOBACTER HEPARINUS
• Total number of polymer chains: 1
• Total formula weight: 55726.58

Authors

Michel, G.,Cygler, M. (deposition date: 2003-04-15, release date: 2004-04-19, Last modification date: 2023-12-13)

• Primary citation: Michel, G.,Pojasek, K.,Li, Y.,Sulea, T.,Linhardt, R.,Raman, R.,Prabhakar, V.,Sasisekharan, R.,Cygler, M.; The Structure of Chondroitin B Lyase Complexed with Glycosaminoglycan Oligosaccharides Unravels a Calcium-Dependent Catalytic Machinery; J.Biol.Chem., 279:32882-, 2004; PubMed: 15155751; DOI: 10.1074/JBC.M403421200

Experimental method

X-RAY DIFFRACTION (1.8 Å)