1OB7

Cephaibol C

1OB7 の概要

• エントリーDOI: 10.2210/pdb1ob7/pdb
• 関連するPDBエントリー: 1AMT 1DLZ 1EE7 1GQ0 1IH9 1JOH 1M24 1OB4 1OB6 1R9U
• 関連するBIRD辞書のPRD_ID: PRD_000158
• 分子名称: CEPHAIBOL C, ETHANOL, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: ion channel, cephaibol, peptaibol, antibacterial, antifungal, antibiotic
• 由来する生物種: ACREMONIUM TUBAKII
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1770.12

構造登録者

Bunkoczi, G.,Schiell, M.,Vertesy, L.,Sheldrick, G.M. (登録日: 2003-01-24, 公開日: 2003-12-11, 最終更新日: 2025-04-09)

主引用文献

Bunkoczi, G.,Schiell, M.,Vertesy, L.,Sheldrick, G.M.
Crystal Structures of Cephaibols
J.Pept.Sci., 9:745-, 2003

PubMed Abstract: The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function.

PubMed: 14658793
DOI: 10.1002/PSC.496

実験手法

X-RAY DIFFRACTION (0.89 Å)