1JOH

THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE

Summary for 1JOH

Entry DOI	10.2210/pdb1joh/pdb
Related	1AMT 1DLZ 1EE7 1GQ0 1IH9 1M24 1OB4 1OB6 1OB7 1R9U
Related PRD ID	PRD_000161
Descriptor	ANTIAMOEBIN I, METHANOL (2 entities in total)
Functional Keywords	antiamoebin i, peptaibol, antibacterial, antifungal, antibiotic
Biological source	EMERICELLOPSIS
Total number of polymer chains	2
Total formula weight	4046.95
Authors	Snook, C.F.,Wallace, B.A. (deposition date: 1997-10-11, release date: 1999-01-20, Last modification date: 2024-12-25)
Primary citation	Snook, C.F.,Woolley, G.A.,Oliva, G.,Pattabhi, V.,Wood, S.F.,Blundell, T.L.,Wallace, B.A. The Structure and Function of Antiamoebin I, a Proline-Rich Membrane-Active Polypeptide. Structure, 6:783-, 1998 Cited by PubMed Abstract: Antiamoebin is a member of the peptaibol family of polypeptides and has a unique antibiotic activity: it acts as an antiamoebic agent, but does not effectively haemolyze erythrocytes even though it does exhibit membrane-modifying activity. PubMed: 9655831 DOI: 10.1016/S0969-2126(98)00079-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation