1OB4
Cephaibol A
Summary for 1OB4
| Entry DOI | 10.2210/pdb1ob4/pdb |
| Related | 1AMT 1DLZ 1EE7 1GQ0 1IH9 1JOH 1M24 1OB6 1OB7 1R9U |
| Related PRD ID | PRD_000156 |
| Descriptor | CEPHAIBOL A, ETHANOL (3 entities in total) |
| Functional Keywords | ion channel, cephaibol, peptaibol, antibacterial, antifungal, antibiotic |
| Biological source | ACREMONIUM TUBAKII |
| Total number of polymer chains | 1 |
| Total formula weight | 1701.06 |
| Authors | Bunkoczi, G.,Schiell, M.,Vertesy, L.,Sheldrick, G.M. (deposition date: 2003-01-24, release date: 2003-12-11, Last modification date: 2019-05-22) |
| Primary citation | Bunkoczi, G.,Schiell, M.,Vertesy, L.,Sheldrick, G.M. Crystal Structures of Cephaibols J.Pept.Sci., 9:745-, 2003 Cited by PubMed Abstract: The crystal structures of the peptaibol antibiotics cephaibol A, cephaibol B and cephaibol C have been determined at ca. 0.9 A resolution. All three adopt a helical conformation with a sharp bend (of about 55 degrees) at the central hydroxyproline. All isovalines were found to possess the D configuration, superposition of all four models (there are two independent molecules in the cephaibol B structure) shows that the N-terminal helix is rigid and the C-terminus is flexible. There are differences in the hydrogen bonding patterns for the three structures that crystallize in different space groups despite relatively similar unit cell dimensions, but only in the case of cephaibol C does the packing emulate the formation of a membrane channel believed to be important for their biological function. PubMed: 14658793DOI: 10.1002/PSC.496 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.95 Å) |
Structure validation
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