1O5E
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
Summary for 1O5E
Entry DOI | 10.2210/pdb1o5e/pdb |
Related | 1p57 |
Descriptor | Serine protease hepsin, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE, ... (4 entities in total) |
Functional Keywords | srcr, scavenger receptor cysteine-rich domain, serine protease ala190 upa, s1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor viia, serine protease, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type II membrane protein: P05981 P05981 |
Total number of polymer chains | 2 |
Total formula weight | 40458.24 |
Authors | Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E. (deposition date: 2003-09-09, release date: 2004-09-21, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J.Mol.Biol., 344:527-547, 2004 Cited by PubMed: 15522303DOI: 10.1016/j.jmb.2004.09.032 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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