1O5B

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

1O5B の概要

• エントリーDOI: 10.2210/pdb1o5b/pdb
• 関連するPDBエントリー: 1gjc
• 分子名称: Urokinase-type plasminogen activator, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CITRIC ACID, ... (5 entities in total)
• 機能のキーワード: ala190 upa, s1 site, selectivity, conserved water displacement hydrogen bond deficit, trypsin, thrombin, hepsin, factor viia, blood clotting, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00749 P00749
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32007.13

構造登録者

Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E. (登録日: 2003-09-09, 公開日: 2004-09-21, 最終更新日: 2023-12-27)

• 主引用文献: Katz, B.A.,Luong, C.,Ho, J.D.,Somoza, J.R.,Gjerstad, E.,Tang, J.,Williams, S.R.,Verner, E.,Mackman, R.L.,Young, W.B.,Sprengeler, P.A.,Chan, H.,Mortara, K.,Janc, J.W.,McGrath, M.E.; Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA); J.Mol.Biol., 344:527-547, 2004; PubMed: 15522303; DOI: 10.1016/j.jmb.2004.09.032

実験手法

X-RAY DIFFRACTION (1.85 Å)