1O0K

Structure of the First Parallel DNA Quadruplex-drug Complex

1O0K の概要

• エントリーDOI: 10.2210/pdb1o0k/pdb
• 分子名称: 5'-D(*TP*GP*GP*GP*GP*T)-3', SODIUM ION, DAUNOMYCIN, ... (4 entities in total)
• 機能のキーワード: g-4 quadruplex drug complex, parallel quadruplex, dna
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 9172.53

構造登録者

Clark, G.R.,Pytel, P.D.,Squire, C.J.,Neidle, S. (登録日: 2003-02-22, 公開日: 2003-04-15, 最終更新日: 2024-04-03)

主引用文献

Clark, G.R.,Pytel, P.D.,Squire, C.J.,Neidle, S.
Structure of the First Parallel DNA Quadruplex-drug Complex
J.Am.Chem.Soc., 125:4066-4067, 2003

PubMed Abstract: The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.

PubMed: 12670225
DOI: 10.1021/ja0297988

実験手法

X-RAY DIFFRACTION (1.17 Å)